Casper Is a FADD- and Caspase-Related Inducer of Apoptosis
نویسندگان
چکیده
منابع مشابه
Activation of NF - k B by FADD , Casper , and Caspase - 8 *
Fas-associated death domain protein (FADD), caspase-8-related protein (Casper), and caspase-8 are components of the tumor necrosis factor receptor type 1 (TNF-R1) and Fas signaling complexes that are involved in TNF-R1and Fas-induced apoptosis. Here we show that overexpression of FADD and Casper potently activates NF-kB. In the presence of caspase inhibitors, overexpression of caspase-8 also ac...
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TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a member of the tumor necrosis factor family that can kill a wide variety of tumor cells but not normal cells. TRAIL-induced apoptosis in humans is mediated by its receptors DR4 (TRAIL-R1) and DR5 (TRAIL-R2). What constitutes the signaling molecules downstream of these receptors, however, remains highly controversial. Using the ...
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The adapter protein FADD consists of two protein interaction domains: a death domain and a death effector domain. The death domain binds to activated death receptors such as Fas, whereas the death effector domain binds to procaspase 8. An FADD mutant, which consists of only the death domain (FADD-DD), inhibits death receptor-induced apoptosis. FADD-DD can also activate a mechanistically distinc...
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Detachment of most untransformed adherent cells from the extracellular matrix promotes apoptosis, in a process termed anoikis [1] [2]. The death signalling mechanisms involved in this process are not known, although adhesion or transformation by ras oncogenes have been shown to protect epithelial cells from apoptosis through activation of phosphatidylinositol 3-kinase and protein kinase B (PKB/...
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ژورنال
عنوان ژورنال: Immunity
سال: 1997
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80450-1